期刊
LAB ON A CHIP
卷 14, 期 19, 页码 3850-3859出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc00707g
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资金
- National Science Foundation (NSF) Cyber-Physical Systems Program [CNS-1135850]
- NSF Graduate Research Fellowship [09468251]
- Division Of Computer and Network Systems
- Direct For Computer & Info Scie & Enginr [1135850] Funding Source: National Science Foundation
Bio-hybrid devices, which integrate biological cells with synthetic components, have opened a new path in miniaturized systems with the potential to provide actuation and control for systems down to a few microns in size. Here, we address the challenge of remotely controlling bio-hybrid microswimmers propelled by multiple bacterial cells. These devices have been proposed as a viable method for targeted drug delivery but have also been shown to exhibit stochastic motion. We demonstrate a method of remote magnetic control that significantly reduces the stochasticity of the motion, enabling steering control. The demonstrated microswimmers consist of multiple Serratia marcescens (S. marcescens) bacteria attached to a 6 mu m-diameter superparamagnetic bead. We characterize their motion and define the parameters governing their controllability. We show that the microswimmers can be controlled along two-dimensional (2-D) trajectories using weak magnetic fields (<= 10 mT) and can achieve 2-D swimming speeds up to 7.3 mu m s(-1). This magnetic steering approach can be integrated with sensory-based steering in future work, enabling new control strategies for bio-hybrid microsystems.
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