期刊
LAB ON A CHIP
卷 13, 期 8, 页码 1612-1618出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc41342j
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资金
- Ministry of Science and Technology [2012AA022703, 2012AA030608, 2011CB933201, 2009CB930001]
- National Science Foundation of China [21025520, 51073045, GZ 614, 91213305]
- Chinese Academy of Sciences [KJCX2-YW-M15]
- K. C. Wong Education Foundation
- China Postdoctoral Science Foundation [20100480246]
- State Major Scientific and Technological Project of China [2013ZX09507005]
Engineering functional vascular networks in vitro is critical for tissue engineering and a variety of applications. There is still a general lack of straightforward approaches for recapitulating specific structures and functions of vasculature. This report describes a microfluidic method that utilizes fibrillogenesis of collagen and a liquid mold to engineer three-dimensional vascular networks in hydrogel. The well-controlled vascular network demonstrates both mechanical stability for perfusing solutions and biocompatibility for cell adhesion and coverage. This technique enables the mimicry of passive diffusion in a nephron one of the main routes transferring soluble organic molecules. This approach could be used for in vitro modelling of mass transfer-involved physiology in vasculature-rich tissues and organs for regeneration and drug screening.
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