期刊
LAB ON A CHIP
卷 13, 期 18, 页码 3555-3561出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc50227a
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资金
- German Federal Ministry of Education and Research (BMBF) [0315569]
- Russian Ministry for Science [16.522.12.2015, 16.522.11.7057]
- DFG through the Berlin-Brandenburg School for Regenerative Therapies [GSC203]
Substantial progress has been achieved over the last few decades in the development of skin equivalents to model the skin as an organ. However, their static culture still limits the emulation of essential physiological properties crucial for toxicity testing and compound screening. Here, we describe a dynamically perfused chip-based bioreactor platform capable of applying variable mechanical shear stress and extending culture periods. This leads to improvements of culture conditions for integrated in vitro skin models, ex vivo skin organ cultures and biopsies of single hair follicular units.
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