期刊
LAB ON A CHIP
卷 12, 期 3, 页码 574-581出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc20586f
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资金
- National Science Foundation [DMI 0328162, ECCS 09-24062]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [0924062] Funding Source: National Science Foundation
In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.
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