期刊
LAB ON A CHIP
卷 12, 期 20, 页码 3861-3865出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc40445a
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资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science of Technology (MEST) [2010-0023975]
- World Class University (WCU) program
- Korean government (MEST) through the National Research Foundation of Korea [R312010000100860]
- Singapore MIT Alliance for Research and Technology (SMART)
Spatiotemporal analysis of the inflammatory response has been limited by the difficulties of in vivo imaging and reconstitution of inflammation in vitro. Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process. This enabled us to concurrently characterize transendothelial migration behaviors of neutrophils under the influence of various inflammatory stimuli.
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