期刊
LAB ON A CHIP
卷 11, 期 7, 页码 1276-1279出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0lc00684j
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资金
- NSF [0754880, 930501]
- Office of The Director, NIH [DP2OD006427]
- Gates Foundation
- Vodafone Americas Foundation
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB009222] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD006427] Funding Source: NIH RePORTER
We report a portable lensless on-chip microscope that can achieve < 1 mu m resolution over a wide field-of-view of similar to 24 mm(2) without the use of any mechanical scanning. This compact on-chip microscope weighs similar to 95 g and is based on partially coherent digital in-line holography. Multiple fiber-optic waveguides are butt-coupled to light emitting diodes, which are controlled by a low-cost micro-controller to sequentially illuminate the sample. The resulting lensfree holograms are then captured by a digital sensor-array and are rapidly processed using a pixel super-resolution algorithm to generate much higher resolution holographic images (both phase and amplitude) of the objects. This wide-field and high-resolution on-chip microscope, being compact and light-weight, would be important for global health problems such as diagnosis of infectious diseases in remote locations. Toward this end, we validate the performance of this field-portable microscope by imaging human malaria parasites (Plasmodium falciparum) in thin blood smears. Our results constitute the first-time that a lensfree on-chip microscope has successfully imaged malaria parasites.
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