期刊
LAB ON A CHIP
卷 11, 期 14, 页码 2316-2318出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1lc20306a
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资金
- Robert W. Deutsch Foundation
- NSF-EFRI [NSF-SC03524414]
Programmable 3D cell assembly under physiological pH conditions is achieved using electrodeposited stimuli-responsive alginate gels in a microfluidic device, with parallel sidewall electrodes enabling direct observation of the cell assembly. Electrically triggered assembly and subsequent viability of mammalian cells is demonstrated, along with spatially programmable, multi-address assembly of different strains of E. coli cells. Our approach enables in vitro study of dynamic cellular and inter-cellular processes, from cell growth and stimulus/response to inter-colony and inter-species signaling.
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