期刊
LAB ON A CHIP
卷 10, 期 18, 页码 2419-2423出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c004829a
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资金
- Office of Naval Research (ONR)
- Office of The Director, National Institutes of Health [DP2OD006427]
- Okawa Foundation
- Vodafone Americas Foundation
- DARPA DSO [56556-MS-DRP]
- NSF [0754880, 0930501]
- NIH [1R21EB009222-01]
- AFOSR [08NE255]
- Directorate For Engineering [0954482] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [0754880, 0930501] Funding Source: National Science Foundation
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB009222] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD006427] Funding Source: NIH RePORTER
Protection of human health and well-being through water quality management is an important goal for both the developed and the developing parts of the world. In the meantime, insufficient disinfection techniques still fail to eliminate pathogenic contaminants in freshwater as well as recreational water resources. Therefore, there is a significant need for screening of water quality to prevent waterborne outbreaks and incidents of water-related diseases. Toward this end, here we investigate the use of a field-portable and cost-effective lensfree holographic microscope to image and detect pathogenic protozoan parasites such as Giardia Lamblia and Cryptosporidium Parvum at low concentration levels. This compact lensless microscope (O. Mudanyali et al., Lab Chip, 2010, 10, 1417-1428), weighing similar to 46 grams, achieves a numerical aperture of similar to 0.1-0.2 over an imaging field of view that is more than an order of magnitude larger than a typical 10X objective lens, and therefore may provide an important high-throughput analysis tool for combating waterborne diseases especially in resource limited settings.
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