期刊
LAB ON A CHIP
卷 10, 期 4, 页码 519-521出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b922830f
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- trans-NIH Genes, Environment and Health Initiative, Biological Response Indicators of Environmental Stress Center [U54 ES016115-01]
- Robert Bosch Corporation
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [U54ES016115] Funding Source: NIH RePORTER
Microfluidic systems offer an attractive alternative to conventional wet chemical methods with benefits including reduced sample and reagent volumes, shorter reaction times, high-throughput, automation, and low cost. However, most present microfluidic systems rely on external means to analyze reaction products. This substantially adds to the size, complexity, and cost of the overall system. Electronic detection based on sub-millimetre size integrated circuits (ICs) has been demonstrated for a wide range of targets including nucleic and amino acids, but deployment of this technology to date has been limited due to the lack of a flexible process to integrate these chips within microfluidic devices. This paper presents a modular and inexpensive process to integrate ICs with microfluidic systems based on standard printed circuit board (PCB) technology to assemble the independently designed microfluidic and electronic components. The integrated system can accommodate multiple chips of different sizes bonded to glass or PDMS microfluidic systems. Since IC chips and flex PCB manufacturing and assembly are industry standards with low cost, the integrated system is economical for both laboratory and point-of-care settings.
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