期刊
LAB ON A CHIP
卷 10, 期 9, 页码 1167-1173出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b920062b
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资金
- European Commission [IST-2005-034562]
- Roberto Rocca Project
Ultrafast laser writing of waveguides in glasses is a very flexible and simple method for direct on-chip integration of photonic devices. In this work we present a monolithic optofluidic device in fused silica providing label-free and spatially-resolved sensing in a microfluidic channel. A Mach-Zehnder interferometer is inscribed with the sensing arm orthogonally crossing the microfluidic channel and the reference arm passing over it. The interferometer is integrated either with a microchannel fabricated by femtosecond laser technology or into a commercial lab-on-chip for capillary electrophoresis. The device layout, made possible by the unique three-dimensional capabilities of the technique, enables label-free sensing of samples flowing in the microchannel with spatial resolution of about 10 mm and limit of detection down to 10(-4) RIU.
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