期刊
PSYCHONEUROENDOCRINOLOGY
卷 62, 期 -, 页码 389-391出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2015.08.028
关键词
Forced swim test; Stress; Depression; Glucocorticoids; Rat; Mouse
The forced swim test is based on the progressive immobility a rodent displays when immersed in a beaker filled with water from where no escape is possible. While the test was originally designed to identify the antidepressant potential of drugs, over the past decade a rapidly growing number of publications (more than 2000) portray this immobility response anthropomorphically as a measure for depression and despair. This is incorrect. The response to the forced swim stressor should be considered for what it shows: a switch from active to passive behavior in the face of an acute stressor, aligned to cognitive functions underlying behavioral adaptation and survival. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据