期刊
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
卷 16, 期 4, 页码 249-253出版社
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
DOI: 10.4196/kjpp.2012.16.4.249
关键词
Anthocyanin; Clinical trial; C3G; Pharmacokinetics; Phaseolus vulgaris
资金
- Rural Development Administration, Republic of Korea [PJ007186]
We analyzed the pharmacokinetics of C3G on data from twelve subjects, after 2-week multiple dosing of black bean (Phaseolus vulgaris, Cheongjakong-3-ho) seed coat extract, using the mixed effect analysis method (NONMEM, Ver. 6.2), as well as the conventional non-compartmental method. We also examined the safety and tolerability. The PK analysis used plasma concentrations of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 1/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 h(-1) ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and there were no serious adverse events. In this study, we confirmed that a significant amount of C3G was absorbed in human after given the black bean seed coat extract.
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