期刊
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
卷 14, 期 5, 页码 337-343出版社
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
DOI: 10.4196/kjpp.2010.14.5.337
关键词
5-HT; Development; GABA; Inhibition; LTD; Synaptic plasticity; Visual cortex
资金
- Korea Science and Engineering Foundation [R01 2003 000 10656 0]
- National Research Foundation of Korea [R01-2003-000-10656-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex In a previous study, we suggested that a developmental increase in serotonin [5-hydroxytryptamine (5-HT)] might be involved in the decline of LTP, since 5-HT inhibited its induction In the present study, to further understand the role of 5-HT in a developmental decrease in plasticity, we investigated the effect of 5-HT on the induction of LTD in the pathway from layer 4 to layer 2/3 LTD was inhibited by 5-HT (10 mu M) in 5-week-old rats The inhibitory effect was mediated by activation of 5-HT2 receptors Since 5-HT also regulates the development of visual cortical circuits, we also investigated the role of 5-HT on the development of inhibition The development of inhibition was retarded by chronic (2 weeks) depletion of endogenous 5-HT in 5-week-old rats, in which LTD was reinstated These results suggest that 5-HT regulates the induction of LTD directly via activation of 5-HT2 receptors and indirectly by regulating cortical development Thus, the present study provides significant insight into the roles of 5-HT on the development of visual cortical circuits and on the age-dependent decline of long-term synaptic plasticity
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