4.5 Article

3D strain in native medial meniscus is comparable to medial meniscus allograft transplant

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SPRINGER
DOI: 10.1007/s00167-018-5075-3

关键词

Meniscus allograft transplantation; MAT; Meniscus; Strain

资金

  1. Musculoskeletal Transplant Foundation (MTF)

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Injury or degeneration of the meniscus has been associated with the development of osteoarthritis of the knee joint. Meniscal allograft transplant (MAT) has been shown to reduce pain and restore function in patients who remain symptomatic following meniscectomy. The purpose of this study is to evaluate and compare the three-dimensional (3D) strain in native medial menisci compared to allograft-transplanted medial menisci in both the loaded and unloaded states. Ten human cadaveric knees underwent medial MAT, utilizing soft-tissue anterior and posterior root fixation via transosseous sutures tied over an anterolateral proximal tibial cortical bone bridge. The joint was imaged first in the non-loaded state, then was positioned at 5A degrees of flexion and loaded to 1x body weight (650 +/- 160 N) during MR image acquisition. Anatomical landmarks were chosen from each image to create a tibial coordinate system, which were then input into a custom-written program (Matlab R2014a) to calculate the 3D strain from the unloaded and loaded marker positions. Six independent strains were obtained: three principal strains and three shearing strains. No statistically significant difference was found between the middle and posterior strains in the native knee compared to the meniscus allograft. This would suggest that soft-tissue fixation of meniscal allografts results in similar time zero principal and shear strains in comparison to the native meniscus. These results suggest that time zero MAT performs in a similar manner to the native meniscus. Optimizing MAT strain behavior may lead to potential improvements in its chondroprotective effect.

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