期刊
PSYCHO-ONCOLOGY
卷 25, 期 5, 页码 582-589出版社
WILEY
DOI: 10.1002/pon.3965
关键词
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资金
- Swedish Cancer Society [99 0347, 01 0235, 02 0690, 03 0227, 05 0189, 10 0649, 11 0649, 12 0649]
- Swedish Childhood Cancer Foundation [1999/021, 02/002, 04/011, 07/044, 10/086]
ObjectiveThe main aim was to investigate the development of health-related quality of life (HRQOL) and symptoms of anxiety and depression in a cohort diagnosed with cancer during adolescence from shortly after up to 10years after diagnosis. MethodsParticipants (n=61) completed the SF-36 and the HADS shortly; six, 12, and 18months; and two, three, four, and 10years (n=28) after diagnosis. Polynomial change trajectories were used to model development. ResultsPolynomial change trajectories showed an initial increase which abated over time into a decrease which abated over time for the SF-36 subscales Mental Health and Vitality; an initial decline which abated over time into an increase for HADS anxiety; and an initial decline which abated over time into an increase which abated over time for HADS depression. The SF-36 mental component summary showed no change from two to 10years after diagnosis whereas the SF-36 physical component summary showed an increase from two years after diagnosis which declined over time. Ten years after diagnosis 29% reported possible anxiety. ConclusionsDevelopment of HRQOL and symptoms of anxiety and depression appears to be non-linear among persons diagnosed with cancer during adolescence. Well into permanent survivorship an increase in symptoms of anxiety is shown and approximately a third of the participants report possible anxiety. The findings indicate the need for: studies designed to pinpoint the times of highest psychological risk, clinical follow-up focusing on psychological problems, and development of effective psychological interventions for survivors of adolescent cancer. (c) 2015 The Authors. Psycho-Oncology published by John Wiley & Sons Ltd.
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