期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 232, 期 2, 页码 145-153出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2015.03.001
关键词
Schizophrenia; fMRI; Resting state; Functional connectivity; Neural networks
资金
- National Natural Science Foundation of China [81130024, 30530300, 30125014]
- Ph.D. Programs Foundation of the Ministry of Education of China [20110181110014]
- National Key Technology R & D Program of the Ministry of Science and Technology of China during the 12th Five-Year Plan [2012BAI01B00]
- NARSAD Independent Investigator Award
- National Basic Research Program of China (973 Program) [2007CB512301]
- Wellcome Trust Collaborative Research Initiative Grant
- Chinese National Nature and Science Foundation [81071089]
- Doctoral Fund of Ministry of Education of China [20110181120033]
- National Institutes of Health from the National Institute of Mental Health [R01MH098003]
- National Institute of Neurological Disorders and Stroke [R01NS085200]
Dysconnectivity between key brain systems has been hypothesized to underlie the pathophysiology of schizophrenia. The present study examined the pattern of functional dysconnectivity across whole-brain neural networks in 121 first-episode, treatment-naive patients with schizophrenia by using resting-state functional magnetic resonance imaging (rsfMRI). Group independent component analysis (ICA) was first applied to rsfMRI data to extract 90 functional components of the brain. The functional connectivity between these ICA components was then evaluated and compared between the patient and control groups. To examine the functional roles of significantly altered between component connections in patients, each ICA component was ascribed to one of 10 previously well-defined brain networks/areas. Relative to findings in healthy controls (n=103), 29 altered functional connections including 19 connections with increased connectivity and 10 connections with decreased connectivity in schizophrenia patients were found. Increased connectivity was mainly within the default mode network (DMN) and between the DMN and cognitive networks, whereas decreased connectivity was predominaritly associated with sensory networks. Given the key roles of the DMN in internal mental processes and sensory networks in inputs from the external environment, these patterns of altered brain network connectivity could suggest imbalanced neural processing of internal and external information in schizophrenia. (C) 2015 Elsevier Ireland Ltd. All rights reserved,
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