期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 233, 期 2, 页码 125-130出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2015.05.006
关键词
Addiction; Alcohol; Inferior frontal gyrus; Gray matter volume; Response inhibition; Stop-signal task
资金
- German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, FOR 1617) [HE2597/14-1]
- Berlin School of Mind and Brain
- Humboldt Graduate School
Impairment in inhibitory control has been proposed to contribute to habitual alcohol use, abuse and eventually dependence. Moreover, alcohol dependent (AD) patients have shown a loss of gray matter volume (GMV) in the brain, specifically in prefrontal regions associated with executive functions, including response inhibition. To date, no study has evaluated whether this prefrontal GMV reduction is related to response inhibition in alcohol dependence. To address this issue, we acquired high resolution TI weighted magnetic resonance mages from recently detoxified AD patients (n=22) and healthy controls (HC; n=21). Differences in local GMV beLvveen groups were assessed by means of voxel-based morphometry (VW). Moreover, within the AD group, mean local GMV reductions were extracted and correlated with behavioral performance on the stop signal task. We found a significantly decrease in GMV in the left inferior frontal gyms (IFG) in AD patients compared with HC subjects. Further, mean local GMV in this area correlated positively with reaction Limes on go trials during the stop signal task in AD patients. Our findings suggest that GMV losses in the IFG in AD patients are related to faster go responses on the stop signal task. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据