Metabolic and inflammatory genes in schizophrenia

Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPAR gamma, SREBP1, IL-6 and TNF alpha, and decreases in PPAR alpha and C/EPB alpha and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia. Published by Elsevier Ireland Ltd.