期刊
PSYCHIATRY RESEARCH
卷 226, 期 1, 页码 230-234出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2014.12.053
关键词
Inflammatory; Methadone; Cytokine
类别
资金
- National Science Council [NSC 102-2320-B-039-024]
Opioid addiction influences many physiological functions including reactions of the immune system. The objective of this study was to investigate the immune system function in heroin addicted patients undergoing methadone maintenance treatment (MMT) compared to healthy controls. We tested the cytokine production of IL-1 beta, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF)-alpha from a group of heroin addicts (n=34) and healthy controls (n=20). The results show that production of IL-1 beta, IL-6 and IL-8 was significantly higher in the group of methadone-maintained patients than in the healthy control group. Plasma TNF-alpha and IL-6 levels were significantly correlated with the dairy methadone dosage administered, and the IL-1 beta level was significantly correlated with the duration of methadone maintenance treatment. These findings suggest that methadone maintenance treatment influences the immune system functions of opioid-dependent patients and may also induce long-term systemic inflammation. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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