期刊
PSYCHIATRY RESEARCH
卷 227, 期 1, 页码 46-51出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2015.02.016
关键词
Depressive symptoms; Vitamin D; Seasonal affective disorder
类别
资金
- Endowment for Health and Human Performance of Good Samaritan Hospital Foundation
- National Institute of Environmental Health Sciences (NIEHS) [P30 ES000210]
There have been few studies of whether vitamin D insufficiency is linked with depression in healthy young women despite women's high rates of both problems. Female undergraduates (n=185) living in the Pacific Northwest during fall, winter, and spring academic terms completed the Center for Epidemiologic Studies Depression (CES-D) scale weekly for 4 weeks (W1-W5). We measured serum levels of vitamin D-3 and C (ascorbate; as a control variable) in blood samples collected at W1 and W5. Vitamin D insufficiency (< 30 ng/mL) was common at W1 (42%) and W5 (46%), and rates of clinically significant depressive symptoms (CES-D >= 16) were 34-42% at W1-W5. Lower W1 vitamin D-3 predicted clinically significant depressive symptoms across WI-W5 (beta= -0.20, p <0.05), controlling for season, BMI, race/ethnicity, diet, exercise, and time outside. There was some evidence that lower levels of depressive symptoms in Fall participants (vs. Winter and Spring) were explained by their higher levels of vitamin D-3. W1 depressive symptoms did not predict change in vitamin D3 levels from W1 to W5. Findings are consistent with a temporal association between low levels of vitamin D and clinically meaningful depressive symptoms. The preventive value of supplementation should be tested further. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据