期刊
PSYCHIATRY RESEARCH
卷 229, 期 3, 页码 901-904出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2015.07.041
关键词
First-episode; Schizophrenia; Metabolism; Diabetes; Dyslipidemia; Cholesterol
类别
Diabetes and dyslipidemia are common in patients with psychosis; this association may be partly related to adverse metabolic effects of antipsychotic medications. We assessed glucose and lipid metabolism during the fasted state in drug-naive patients with psychosis. Fasting serum concentrations of total cholesterol, triglycerides, high density lipoprotein (HDL), glucose, insulin, connecting peptide (C-peptide), homeostatic model assessment index (HOMA-IR), glycated hemoglobin (HbA1C) and serum cortisol were compared between a group of 40 newly diagnosed drug-naive, first-episode patients with psychosis and a group of 40 healthy controls, matched for age, sex and BMI. Total cholesterol, triglycerides and fasting glucose levels were similar, whereas insulin and C-peptide levels were higher and HDL marginally lower in the patients' group compared to those in healthy controls. Drug-naive patients with psychosis were more insulin resistant (as assessed by the HOMA-R index) compared to healthy controls. Serum cortisol did not differ between the two groups. There is evidence that drug-naive, first-episode patients with psychosis are more insulin resistant compared to healthy controls. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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