Adenosine A2A agonists as therapy for glomerulonephritis

Garcia et al. report the utility of pharmacological activation of the adenosine A(2A) receptor (A(2A)R) in preserving renal function, reversing fibrosis, and reducing macrophage infiltration and inflammatory activation in rat nephrotoxic nephritis. The role of A(2A)R activation in determining outcome in renal inflammation is discussed. Kidney International (2011) 80, 329-331. doi:10.1038/ki.2011.167