期刊
KIDNEY INTERNATIONAL
卷 78, 期 -, 页码 S22-S26出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2010.418
关键词
B cell; fibrosis; inflammation; leukocyte; macrophage; T cell
资金
- Stromedix, Inc.
- US National Institutes of Health [DK55001, DK62987, DK13193, DK61688]
- PKD Foundation
- Division of Matrix Biology at the Beth Israel Deaconess Medical Center
- Pusan National University, Busan, Korea
Fibrosis of the kidney is caused by the prolonged injury and deregulation of normal wound healing and repair processes, and by an excess deposition of extracellular matrices. Despite intensive research, our current understanding of the precise mechanism of fibrosis is limited. There is a connection between fibrotic events involving inflammatory and noninflammatory glomerulonephritis, inflammatory cell infiltration, and podocyte loss. The current review will discuss the inflammatory response after renal injury that leads to fibrosis in relation to non-inflammatory mechanisms.
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