期刊
KIDNEY INTERNATIONAL
卷 76, 期 8, 页码 893-899出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2009.289
关键词
acute kidney injury; end-stage renal disease; epidemiology
资金
- National Institutes of Health [R01 DK67126, U01 DK82223]
To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days following hospital discharge. The study encompassed 556,090 adult members of Kaiser Permanente of Northern California hospitalized over an 8 year period, who had pre-admission estimated glomerular filtration rates (eGFR) equivalent to or greater than 45 ml/min/1.73 m(2) and who survived hospitalization. After controlling for potential confounders such as baseline level of eGFR and diabetes status, dialysis-requiring ARF was independently associated with a 28-fold increase in the risk of developing stage 4 or 5 CKD and more than a twofold increased risk of death. Our study shows that in a large, community-based cohort of patients with pre-existing normal or near normal kidney function, an episode of dialysis-requiring ARF was a strong independent risk factor for a long-term risk of progressive CKD and mortality. Kidney International (2009) 76, 893-899; doi:10.1038/ki.2009.289; published online 29 July 2009
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