期刊
KIDNEY INTERNATIONAL
卷 73, 期 9, 页码 989-991出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2008.104
关键词
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Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PPi), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PPi by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.
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