期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 74, 期 1, 页码 44-51出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gly174
关键词
APOE; Extreme human longevity; Genetic association; Survival distribution
资金
- National Institute on Aging (NIA) [U01-AG023755, U19-AG023122, R21AG056630]
- National Institute of General Medical Sciences (NIGMS) Interdisciplinary Training Grant for Biostatisticians Program [T32 GM74905]
- William M. Wood Foundation
- Paulette and Marty Samowitz Family Foundation
- NIA [U01AG009740, RC2AG036495, RC4AG039029]
- Nathan Shock Centers of Excellence in the Basic Biology of Aging [P30AG038072]
- NIH/NIA [1 R01AG044829, 1 R01 AG 042188-01, NIH-1 R01 AG 046949 -01]
- Danish Agency for Science, Technology and Innovation
- US National Institutes of Health [P01 AG08761]
- Velux Foundation
- AMED Program for an Integrated Database of Clinical and Genomic Information
- Program for Initiative Research Projects, Keio University
- Clinical and Translational Science Institute, Boston University [1UL1TR001430]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR001430] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM074905] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG046949, P30AG038072, R01AG044829, U19AG023122, P01AG031719, R21AG056630, U01AG023755, U01AG009740] Funding Source: NIH RePORTER
We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.
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