期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 68, 期 11, 页码 1433-1438出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glt029
关键词
Physical activity; Frailty; Preventative health care; Successful aging
资金
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Jahnsson Foundation
- University Central Hospital of Oulu
- University Central Hospital of Helsinki
- Uulo Arhio Foundation
- Paivikki and Sakari Sohlberg Foundation
- Academy of Finland [138730]
Background. There are scarce studies of the long-term associations between leisure-time physical activity (LTPA) in midlife and phenotypic frailty in old age. Methods. We studied healthy Caucasian men of high socioeconomic status (N = 514), who had participated in health checkups during the 1960s (the Helsinki Businessmen Study, Finland). In 1974, they were examined with questionnaires and clinical examinations, and LTPA was collapsed into three categories: low (n = 87), moderate (n = 256), and high (n = 171). In 2000, at mean age of 74, survivors were assessed for physical activity and frailty phenotype using the modified Fried criteria validated in our cohort. Four criteria were used: (a) weight loss >5% from midlife or current body mass index <21 kg/m(2), (b) physical inactivity, (c) low vitality, and (d) physical weakness. Responders with 3-4, 1-2, and zero criteria were classified as frail, prefrail, and nonfrail, respectively. Results. The prevalence of frailty was 16.1%, 10.2%, and 4.7% in the low, moderate, and high LTPA groups, respectively. Higher midlife LTPA was significantly related to lower prevalence of both frailty and prefrailty in old age. After adjusting for baseline age, smoking, body mass index, blood pressure, and alcohol, the risk of frailty was 80% lower in the high LTPA group compared with the low LTPA group (odds ratio = 0.20; 95% confidence interval 0.07-0.55). This finding was supported by the relationships between the change of physical activity and frailty in old age. Conclusions. In this socioeconomically homogenous male cohort, higher physical activity since midlife was strongly associated with less frailty in old age.
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