期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 69, 期 10, 页码 1186-1198出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glt187
关键词
Mitochondrial biogenesis; p70S6K; Myostatin; IGF-1
资金
- Spanish Ministry of Education and Science (MEC) [SAF2010-19498]
- Red Tematica de investigacion cooperativa en envejecimiento y fragilidad (RETICEF) [ISCIII2006-RED13-027, ISCIII2012-RED-43-029]
- Conselleria de Sanitat de la Generalitat Valenciana [PROMETEO2010/074]
- 35NEURO GentxGent from Fundacio Gent Per Gent de la Comunitat Valenciana
- Fundacion de Investigacion del Hospital Clinico Universitario de Valencia [RS2012-609]
- European Union (EU) [CM1001, FRAILOMIC-HEALTH.2012.2.1.1-2]
- Fondo Europeo de Desarrollo Regional funds from European Union
The aim of our study was to elucidate the role of growth hormone (GH) replacement therapy in three of the main mechanisms involved in sarcopenia: alterations in mitochondrial biogenesis, increase in oxidative stress, and alterations in protein balance. We used young and old Wistar rats that received either placebo or low doses of GH to reach normal insulin-like growth factor-1 values observed in the young group. We found an increase in lean body mass and plasma and hepatic insulin-like growth factor-1 levels in the old animals treated with GH. We also found a lowering of age-associated oxidative damage and an induction of antioxidant enzymes in the skeletal muscle of the treated animals. GH replacement therapy resulted in an increase in the skeletal muscle protein synthesis and mitochondrial biogenesis pathways. This was paralleled by a lowering of inhibitory factors in skeletal muscle regeneration and in protein degradation. GH replacement therapy prevents sarcopenia by acting as a double-edged sword, antioxidant and hypertrophic.
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