期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 68, 期 1, 页码 62-67出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls119
关键词
Frailty; Consensus definition; Older people; Biomarkers
资金
- EU [HEALTH.2010.2.2.2-5, 261270]
- Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad [RD06/0013]
- Instituto de Salud Carlos III, Ministry of Science and Innovation, Spain
- Intramural Research Program of the National Institute on Aging, National Institutes of Health, USA
Background. There is no consensus regarding the definition of frailty for clinical uses. Methods. A modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted. Results. Overall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis. Conclusions. There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.
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