期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 67, 期 12, 页码 1307-1312出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr235
关键词
-
资金
- National Center for Research Resources, a component of the National Institutes of Health [UL1 RR025750, KL2 RR025749, TL1 RR025748]
- NIH Roadmap for Medical Research
- Einstein Diabetes Research and Training Center [5P60 DK20541]
- National Institute on Aging [P01 AG021654-01]
- National Institutes of Health's National Center for Minority Health & Health Disparities [P60 MD000514]
Background. Resveratrol, a plant-derived polyphenol, has shown promising effects on insulin sensitivity and glucose tolerance in animal models and is also reported to have cardioprotective properties, but human studies are limited. In a pilot study, we tested the hypothesis that resveratrol improves glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT). Methods. Ten subjects aged 72 +/- 3 years (M +/- SD) with IGT were enrolled in a 4-week open-label study of resveratrol (daily dose 1, 1.5, or 2 g). Following a standard mixed meal (110 g carbohydrate, 20 g protein, 20 g fat), we measured 3-hour glucose and insulin area under the curve (AUC), insulin sensitivity (Matsuda index), and secretion (corrected insulin response at 30 minutes). Endothelial function was assessed by reactive hyperemia peripheral arterial tonometry (reactive hyperemia index) before and 90 minutes postmeal. Results did not differ by dose, so data were combined for analysis. Results. At baseline, body mass index was 29 +/- 5 kg/m(2), fasting plasma glucose 110 +/- 13 mg/dL, and 2-hour glucose 183 +/- 33 mg/dL. After 4 weeks of resveratrol, fasting plasma glucose was unchanged, but peak postmeal (185 +/- 10 vs 166 +/- 9 mg/dL, p = .003) and 3-hour glucose AUC (469 +/- 23 vs 428 +/- 19, p = .001) declined. Matsuda index improved (3.1 +/- 0.5 vs 3.8 +/- 0.5, p = .03), and corrected insulin response at 30 minutes was unchanged (0.6 +/- 0.1 vs 0.5 +/- 0.5, p = .49). There was a trend toward improved postmeal reactive hyperemia index (baseline vs resveratrol postmeal delta -0.4 +/- 0.2 vs 0.2 +/- 0.3, p = .06). Weight, blood pressure, and lipids were unchanged. Conclusions. At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and postmeal plasma glucose in subjects with IGT. These preliminary findings support the conduct of larger studies to further investigate the effects of resveratrol on metabolism and vascular function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据