期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 67, 期 6, 页码 626-639出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls102
关键词
IGF-1; Oxidant stress; Aging; Atherosclerosis; Inflammation
资金
- National Institutes of Health/National Heart, Lung, and Blood Institute [R01HL070241, R01HL080682]
- National Institutes of Health/National Center for Research Resources [5 P20 RR018766-10]
- National Institutes of Health/National Institute of General Medical Sciences [8 P20 GM103514-10]
Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features of atherosclerotic plaque stability in animal models. Potential mechanisms for this atheroprotective effect include IGF-1-induced reduction in oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction. Aging is associated with increased vascular oxidative stress and vascular disease, suggesting that IGF-1 may exert salutary effects on vascular aging processes. In this review, we will provide a comprehensive update on IGF-1's ability to modulate vascular oxidative stress and to limit atherogenesis and the vascular complications of aging.
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