期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 68, 期 1, 页码 6-16出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls070
关键词
Longevity; Aging; Mice; Diet; Interventions
资金
- National Institute on Aging at the National Institutes of Health [U01-AG022303, U01-AG025707, U01-AG022308, AG13925, U01-AG022307, P30-AG13319]
- Department of Veterans Affairs
- Intramural Research Program of the National Institute on Aging
- NATIONAL EYE INSTITUTE [R01EY007042] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG028730, P30AG025707, U01AG022307, P30AG013319, P30AG024824, U01AG022303, P30AG038070, U01AG022308, R01AG019719, R37AG028730, ZIAAG000363, R01AG013925] Funding Source: NIH RePORTER
The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin. oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.
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