期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 68, 期 3, 页码 258-267出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls143
关键词
Skeletal muscle; Physical function; Monkey; Aging
资金
- National Institutes of Health [AG13934, AG15820, AG020583]
- Wake Forest University Pepper Older Americans Independence Center [P30-AG21332]
- National Center for Research Resources [P40-RR019963]
Previous studies on the contractile properties of human myofibrils reported increase, decrease, or no change with aging, perhaps due to the differences in physical activity, diet, and other factors. This study examined physical performance and contractile characteristics of myofibrils of vastus lateralis (VL) muscle in young adult and old African green vervet monkeys. Animals were offered the same diet and lived in the same enclosures during development, so we were able to examine skeletal muscle function in vivo and in vitro with fewer potential confounding factors than are typical in human research studies. Fiber atrophy alone did not account for the age-related differences in specific force and maximal power output. Regression modeling used to identify factors contributing to lower fiber force revealed that age is the strongest predictor. Our results support a detrimental effect of aging on the intrinsic force and power generation of myofilament lattice and physical performance in vervet monkeys.
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