期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 66, 期 8, 页码 835-841出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr088
关键词
Endurance training; Myofiber; Physical activity; Elderly; Sarcopenia
资金
- National Institute of Aging [AG-32127]
To assess myosin heavy chain (MHC) plasticity in aging skeletal muscle with aerobic exercise training, MHC composition was measured at the messenger RNA (mRNA) level and protein level in mixed-muscle homogenates and single myofibers. Muscle samples were obtained from eight nonexercising women (70 +/- 2 years) before and after 12 weeks of training (20-45 minutes of cycle exercise per session at 60%-80% heart rate reserve, three to four sessions per week). Training elevated MHC I mRNA (p < .10) and protein (p < .05) in mixed-muscle (54% +/- 4% to 61% +/- 2%) and single myofibers (42% +/- 4% to 52% +/- 3%). The increase in MHC I protein was positively correlated (p < .05) with improvements in whole muscle power. Training resulted in a general downregulation of MHC IIa and IIx at the mRNA and protein levels. The training-induced increase in MHC I protein and mRNA demonstrates the maintenance of skeletal muscle plasticity with aging. Furthermore, these data suggest that a shift toward an oxidative MHC phenotype may be beneficial for metabolic and functional health in older individuals.
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