期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 67, 期 6, 页码 573-+出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr208
关键词
Longevity; Collagen; Glycemia; Markers; Oxidative stress
资金
- Zentrum fur Wasser- und Umweltforschung of the University of Duisburg-Essen
- German Society of Laboratory Animal Science GV SOLAS
- German Academic Exchange Service
- National Institute of Diabetes and Digestive and Kidney Diseases [DK079432]
- National Institute on Aging [AG18629]
Mole-rat of the genus Fukomys are mammals whose life span is strongly influenced by reproductive status with breeders far outliving nonbreeders. This raises the important question of whether increased longevity of the breeders is reflected in atypical expression of biochemical markers of aging. Here, we measured markers of glycation and advanced glycation end-products formed in insoluble skin collagen of Ansell's mole-rat Fukomys anselli as a function of age and breeding status. Glucosepane, pentosidine, and total advanced glycation end-product content significantly increased with age after correction for breeder status and sex. Unexpectedly, total advanced glycation end-products, glucosepane, and carboxymethyl-lysine (CML) were significantly higher in breeders versus nonbreeders suggesting that breeders have evolved powerful defenses against combined oxidant and carbonyl stress compared with nonbreeders. Most interestingly, when compared with other mammals, pentosidine formation rate was lower in mole-rat compared with other short-lived rodents confirming previous observations of an inverse relationship between longevity and pentosidine formation rates in skin collagen.
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