期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 66, 期 11, 页码 1152-1162出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr112
关键词
Telomere length; Psychological stress; Epidemiology; Childhood; Emotion
资金
- Medical Research Council UK [G9502233, G0300128]
- Cancer Research UK [C865/A2883, C1287/A9540, C8197/A10123]
- MRC [G0300128] Funding Source: UKRI
- Cancer Research UK [11022, 10118] Funding Source: researchfish
- Medical Research Council [G0401527, G0300128, G1000143] Funding Source: researchfish
We investigated the association between psychological stress, emotional health, and relative mean telomere length in an ethnically homogeneous population of 4,441 women, aged 41-80 years. Mean telomere length was measured using high-throughput quantitative real-time polymerase chain reaction. Social adversity exposure and emotional health were assessed through questionnaire and covariates through direct measurement and questionnaire. This study found evidence that adverse experiences during childhood may be associated with shorter telomere length. This finding remained after covariate adjustment and showed evidence of a dose-response relationship with increasing number of reported childhood difficulties associated with decreasing relative mean telomere length. No associations were observed for any of the other summary measures of social adversity and emotional health considered. These results extend and provide support for some previous findings concerning the association of adverse experience and emotional health histories with shorter telomere length in adulthood. Replication of these findings in longitudinal studies is now essential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据