期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 65, 期 10, 页码 1028-1041出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glq113
关键词
Vascular aging; Oxidative stress; Endothelial dysfunction; Atherosclerosis; Stroke; Myocardial infarction
资金
- American Diabetes Association
- American Federation for Aging Research
- National Institutes of Health (NIH) [HL077256, HL43023, AG11370]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL043023, R01HL077256] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [ZIAAG000362, P01AG011370, ZIAAG000361, ZIAAG000363, ZIAAG000368] Funding Source: NIH RePORTER
This review focuses on molecular, cellular, and functional changes that occur in the vasculature during aging; explores the links between mitochondrial oxidative stress, inflammation, and development of vascular disease in the elderly patients; and provides a landscape of molecular mechanisms involved in cellular oxidative stress resistance, which could be targeted for the prevention or amelioration of unsuccessful vascular aging. Practical interventions for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the effects of anti-inflammatory treatments, regular exercise, dietary interventions, and caloric restriction mimetics.
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