期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 64, 期 8, 页码 819-827出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glp052
关键词
Reactive oxygen species; Liver; Ames dwarf mice; Paraquat; Diquat
资金
- National Institutes of Health [AGO-21890, AG-19316, AG-13319, AG-23843, AG-26557, HL-75360]
- San Antonio Nathan Shock Aging Center [1P30-AG-13319]
- Department of Veterans Affairs Merit Grant
- Department of Veterans Affairs
To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwarf mice still showed greater resistance. Dwarf mice also were more resistant to diquat; 80% of male and 60% of female controls died compared with 40% and 20% of dwarf mice, despite greater sensitivity of dwarf liver to diquat. Dwarf mice were also less sensitive to dobutamine-induced cardiac stress and had lower levels of liver and lung F-2-isoprostanes. This is the first direct in vivo evidence that long-lived Ames dwarf mice have enhanced resistance to chemical insult, particularly oxidative stressors.
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