期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 64, 期 9, 页码 927-939出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glp066
关键词
Voluntary activity; Muscle aging; Sarcopenia; Running wheel; Oxidative stress
资金
- Fundacao para a Ciencia e Tecnologia [PTDC/10DES/70757/2006]
- Programa Operacional Ciencia e Inova Inovacao 2010
- Fundo Social Europeu.
This study investigated the impact of lifelong sedentariness oil skeletal muscle mass and mitochondrial function. Thirty C57BL/6 strain mice (2 months) were randomly divided into three groups (young-Y: old sedentary-M old activc-OA). Young animals were sacrificed after I week of quarantine. and OS and OA groups were individually placed into Standard calves and in cages with running wheels. respectively, until sacrifice (25 months). Body weights and hind-limb skeletal Muscle wet weights were obtained from all groups. Mitochondrial respiratory functional measures (i.e. state 3 and 4 respiration, respiratory control ratio. and ratio of nanomoles of ADP phosphorylated by nanomoles of O-2 consumed [ADP/O]) and biochemical markers of oxidative damage (aconitase activity. protein carbonyl derivatives. sulfhydryl groups) were Measured in isolated mitochondrial Suspensions. Our results reveal that lifelong, sedentary behavior has a negative impact on the age-related loss of skeletal muscle mass and oil the isolated mitochondrial function of mixed skeletal muscle of mice, which is associated with an increased oxidative damage to mitochondrial biomolecules.
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