期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 63, 期 5, 页码 447-453出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/63.5.447
关键词
adiponectin; genetics; longevity; metabolic syndrome; cardiovascular disease
资金
- NCRR NIH HHS [M01-RR12248, M01 RR012248] Funding Source: Medline
- NIA NIH HHS [R01 AG018728, R01 AG18728, R01 AG018728-05] Funding Source: Medline
- NIDDK NIH HHS [P30 DK020541, P60 DK020541, DK 20541] Funding Source: Medline
Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78). Adiponectin levels were significantly greater in participants older than 95 years (p = .01), an effect that was independent of sex and body mass index (BMI). Adiponectin levels in the offspring were higher (following adjustment for age, sex, and BMI) compared to controls (p = .02), suggesting that inherited factors play a role in determining adiponectin levels. Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.
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