期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 63, 期 5, 页码 501-504出版社
GERONTOLOGICAL SOC AMER
DOI: 10.1093/gerona/63.5.501
关键词
APOE; MRI; cerebral atrophy; voxel-based morphometry; hippocampus; amygdala
Background. The APOE*E4 allele has been associated with greater gray matter atrophy and with Alzheimer's disease. The aim of this study was to investigate whether the relationship between cerebral gray matter atrophy and APOE*E4 genotype was also present in a community-dwelling, nondemented 60- to 64-year-old cohort. Methods. Hippocampal and amygdalar volumes were manually traced and analyzed on 331 cranial T1-weighted magnetic resonance imaging (MRI) scans to detect differences associated with APOE*E4 genotype. Voxel-based morphometric (VBM) analyses were applied to detect regional gray matter volume differences. Results. No total, hippocampal, or amygdalar gray matter volume difference was detected between APOE*E4 carriers and noncarriers. Conclusions. In nondemented 60- to 64-year-olds, there was no association between APOE genotype and gray matter volume using both region-of-interest analysis and VBM.
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