期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 63, 期 5, 页码 461-466出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/63.5.461
关键词
antioxidant; aging; disuse
This study investigated the age effect on antioxidant adaptation to muscle disuse. Adult and old rats were randomized into 4 groups: weight bearing (control), 3 days of hind-limb unloading (HU), 7 days of HU, and 14 days of HU. Activities of Cu-Zn superoxide dismutase (SOD), catalase, and glutathione (GSH), as well as GSH peroxidase levels were measured in the soleus. Neither disuse nor aging changed the activity of Cu-Zn SOD. The old rats had greater GSH peroxidase activity, whereas the activity of catalase had a compensatory increase with disuse, independent of age. Reduced GSH level and total glutathione (tGSH) level had age-related change with disuse. In old rats, the GSH and tGSH levels were lower with disuse, whereas the levels remained stable with disuse in adult rats. The depletion of intracellular GSH and tGSH levels of muscles from aged animals with disuse may make aged muscles more susceptible to oxidative damage.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据