期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 10, 期 2, 页码 147-153出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B0820185
关键词
Anti-allergic activity; Brown seaweed; Ethanol extracts; Hyaluronidase Phlorotannin
Ethanol extracts of brown seaweeds from Pakistan and China were isolated and compared for their antiallergenic activities. They included Sargassum tennerimum (ST) and Sargassum cervicorne (SC) from Pakistan, and Sargassum graminifolium turn (SG), Sargassum thunbergii (STH), and Laminaria japonica (LJ) from China. The ethanol extracts of these brown seaweeds were optimized at 85% (v/v) ethanol for the maximum yield of phlorotannin, an inhibitor against hyaluronidase. Total phlorotannins contained in the crude extracts were measured as 1.71% (SG), 0.74% (STH), 0.97% (LJ), 3.30% (SC), and 5.06% (ST). The 50% inhibitory concentrations (IC50) of Pakistani SC and ST were 109.5 and 21 mu g/ml, respectively, lower than those of Chinese SG, STH, and LJ (134, 269, and 148 mu g/ml, respectively). An antiallergic drug, disodium cromoglycate (DSCG), had an IC50=39 mu g/ml, and a natural inhibitor of hyaluronidase, catechin, had an IC50=20 mu g/ml. The IC50 of ST extract was found similar to that of catechin (21 vs 20 mu g/ml) and lower than that of DSCG (21 vs 39 mu g/ml). This suggests that ST is a potent inhibitor of hyaluronidase, indicating a promising future development of natural antiallergic medicines or functional foods.
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