期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 9, 期 6, 页码 506-510出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B0820047
关键词
adefovir dipivoxil (ADV); solid lipid nanoparticles (SLN); octadecylamine-fluorescein isothiocynate (ODA-FITC); hepatitis B virus (HBV)
Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15 wt% drug entrapment efficiency (EE) and 3 wt% drug loading (DL) could be reached in SLN loading ADV. Comparing with free ADV, the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in vitro were significantly enhanced.
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