期刊
PROTEOMICS
卷 15, 期 15, 页码 2705-2715出版社
WILEY
DOI: 10.1002/pmic.201400476
关键词
Biomedicine; Bodily fluids; Mass spectrometry; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Proteomics
资金
- National Institutes of Health [K25CA137222, R21CA149772, R21CA161575, R01CA180949]
- Canary Foundation
- Swim Across America
Proteomics study of pancreatic cancer using bodily fluids emphasizes biomarker discovery and clinical application, presenting unique prospect and challenges. Depending on the physiological nature of the bodily fluid and its proximity to pancreatic cancer, the proteomes of bodily fluids, such as pancreatic juice, pancreatic cyst fluid, blood, bile, and urine, can be substantially different in terms of protein constitution and the dynamic range of protein concentration. Thus, a comprehensive discovery and specific detection of cancer-associated proteins within these varied fluids is a complex task, requiring rigorous experiment design and a concerted approach. While major challenges still remain, fluid proteomics studies in pancreatic cancer to date have provided a wealth of information in revealing proteome alterations associated with pancreatic cancer in various bodily fluids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据