期刊
PROTEIN SCIENCE
卷 24, 期 9, 页码 1543-1548出版社
WILEY
DOI: 10.1002/pro.2717
关键词
odorant receptor; sequence; structure; binding cavity; olfactory
资金
- APEX Region PACA (OLFACTOME)
- Fondation Roudnitska under aegis of Fondation de France
Odorant receptors (ORs) are the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the template is deemed rather minor for identifying residues that constitute the wall of the binding cavity or those involved in G protein recognition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据