4.1 Article

Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

An Antibody against the C-Terminal Domain of PCSK9 Lowers LDL Cholesterol Levels In Vivo

Felix Schiele et al.

JOURNAL OF MOLECULAR BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Proprotein convertase subtilisin/kexin type 9 inhibition

David A. Marais et al.

CURRENT OPINION IN LIPIDOLOGY (2012)

Article Pharmacology & Pharmacy

Using Fragment-Based Technologies to Target Protein-Protein Interactions

Justin F. Bower et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Pharmacology & Pharmacy

Small-Molecule Inhibitors of Protein-Protein Interactions: How to Mimic a Protein Partner

David C. Fry

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Biochemistry & Molecular Biology

Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain

Yingnan Zhang et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Article Biotechnology & Applied Microbiology

Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication

Belete A. Desimmie et al.

MOLECULAR THERAPY (2012)

Review Biotechnology & Applied Microbiology

The biology and therapeutic targeting of the proprotein convertases

Nabil G. Seidah et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Multidisciplinary Sciences

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

Nabil G. Seidah et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor

Oystein L. Holla et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation

Yanqun Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

Paola Lo Surdo et al.

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

Oystein L. Holla et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Biochemistry & Molecular Biology

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

Mali Liu et al.

JOURNAL OF LIPID RESEARCH (2010)

Editorial Material Hematology

The LDL Receptor

Joseph L. Goldstein et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Article Gastroenterology & Hepatology

PCSK9 Impedes Hepatitis C Virus Infection In Vitro and Modulates Liver CD81 Expression

Patrick Labonte et al.

HEPATOLOGY (2009)

Article Biochemistry & Molecular Biology

Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants

Matthew J. Bottomley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels

Gaetan Mayer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

Shilpa Pandit et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Multidisciplinary Sciences

Molecular basis for LDL receptor recognition by PCSK9

Hyock Joo Kwon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain

Eric N. Hampton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemical Research Methods

Protein-protein interaction hotspots carved into sequences

Yanay Ofran et al.

PLOS COMPUTATIONAL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

The crystal structure of PCSK9: A regulator of plasma LDL-cholesterol

Derek E. Piper et al.

STRUCTURE (2007)

Article Biochemistry & Molecular Biology

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

David Cunningham et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Molecular biology of PCSK9: its role in LDL metabolism

Jay D. Horton et al.

TRENDS IN BIOCHEMICAL SCIENCES (2007)

Article Biochemistry & Molecular Biology

New method for fast and accurate binding-site identification and analysis

Tom Halgren

CHEMICAL BIOLOGY & DRUG DESIGN (2007)

Article Medicine, General & Internal

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

JC Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Genetics & Heredity

A spectrum of PCSK9 Alleles contributes to plasma levels of low-density lipoprotein cholesterol

IK Kotowski et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Chemistry, Medicinal

Druggability indices for protein targets derived from NMR-based screening data

PJ Hajduk et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Review Biotechnology & Applied Microbiology

Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream

MR Arkin et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Article Multidisciplinary Sciences

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

KN Maxwell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

JD Horton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Genetics & Heredity

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

M Abifadel et al.

NATURE GENETICS (2003)

Article Multidisciplinary Sciences

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation

NG Seidah et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

KN Maxwell et al.

JOURNAL OF LIPID RESEARCH (2003)

Article Biochemistry & Molecular Biology

On the role of the crystal environment in determining protein side-chain conformations

MP Jacobson et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)