期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 118, 期 -, 页码 11-18出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2015.03.005
关键词
Arachidonic acid metabolites; Targeted metabolomic approach; Hypothyroidism; Hyperthyroidism; Cardiovascular disorders
资金
- Ministry of Science and Technology of China [2010CB912500, 2012CB524905]
- National Natural Science Foundation [31371189, 31100550, 31170809, 81100557]
- SIBS/CAS [SIBS2012004]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- CAS [2012OHTP07]
Symptoms of cardiovascular diseases are frequently found in patients with hypothyroidism and hyperthyroidism. However, it is unknown whether arachidonic acid metabolites, the potent mediators in cardiovascular system, are involved in cardiovascular disorders caused by hyperthyroidism and hypothyroidism. To answer this question, serum levels of arachidonic acid metabolites in human subjects with hypothyroidism, hyperthyroidism and mice with hypothyroidism or thyroid hormone treatment were determined by a mass spectrometry-based method. Over ten arachidonic acid metabolites belonging to three catalytic pathways: cyclooxygenases, lipoxygenases, and cytochrome P450, were quantified simultaneously and displayed characteristic profiles under different thyroid hormone status. The level of 20-hydroxyeicosatetraenoic acid, a cytochrome P450 metabolite, was positively correlated with thyroid hormone level and possibly contributed to the elevated blood pressured in hyperthyroidism. The increased prostanoid (PG) 12 and decreased PGE(2) levels in hypothyroid patients might serve to alleviate atherosclerosis associated with dyslipidemia. The elevated level of thromboxane (TX) A(2), as indicated by TXB2, in hyperthyroid patients and mice treated with thyroid hormone might bring about pulmonary hypertension frequently found in hyperthyroid patients. In conclusion, our prospective study revealed that arachidonic acid metabolites were differentially affected by thyroid hormone status. Certain metabolites may be involved in cardiovascular disorders associated with thyroid diseases. (C) 2015 Elsevier Inc. All rights reserved.
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