期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 121, 期 -, 页码 42-45出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2015.06.006
关键词
Prostaglandin E-2; Microsomal prostaglandin E synthase-1; 15-Hydroxyprostagladin dehydrogenase; Prostaglandin E-2 receptor; Colon carcinogenesis
资金
- Japan Society for the Promotion of Science [25860100, 21390036, 25293033]
- Ministry of Education, Sports, Science, Culture and Technology of Japan [23116515, 25116720]
- Grants-in-Aid for Scientific Research [25860100, 25293033, 25116720, 21390036] Funding Source: KAKEN
Nonsteroidal anti-inflammatory drugs, especially selective cyclooxygenase-2 (COX-2) inhibitors, are among the most promising chemopreventive agents for colorectal cancer. However, recent clinical trials have indicated that these inhibitors pose a significantly increased cardiovascular risk. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) and mPGES-1-derived PGE(2) have gained attention recently as alternative targets to COX-2 for colorectal cancer chemoprevention and chemotherapy. In this review, we summarize the current understanding of the roles of mPGES-1, a PGE(2)-inactivating enzyme (15-hydroxyprostagladin dehydrogenase), and PGE(2) specific receptors (EPs) in colon carcinogenesis. (c) 2015 Elsevier Inc. All rights reserved.
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