期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 116, 期 -, 页码 104-111出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2015.02.001
关键词
Omega-3 fatty acids; Inflammation; C-reactive protein; Clinical research; Human endotoxemia model
资金
- Pronova BioPharma
- GlaxoSmithKline
- Baxter Pharmaceuticals
Chronic inflammation is a common underpinning of many diseases. There is a strong pre-clinical evidence base demonstrating the efficacy of omega-3 fatty acids for ameliorating inflammation and thereby reducing disease burden. Clinically, C-reactive protein (CRP) serves as both a reliable marker for monitoring inflammation and a modifiable endpoint for studies of anti-inflammatory pharmaceuticals. However, clinical omega-3 fatty acid supplementation trials have not replicated pre-clinical findings in terms of consistent CRP reductions. Methodological differences present numerous challenges in translating preclinical evidence to clinical results. It is crucial that future clinical nutrition research clearly distinguish between the reversal of established inflammation and preventing the development of inflammation. Future clinical studies evaluating the ability of omega-3 fatty acids to attenuate an excessive inflammatory response, may be advanced by employing new statistical approaches and utilizing models of induced inflammation, such as low-dose human endotoxemia. (C) 2015 Elsevier Inc. All rights reserved.
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